Cascade reaction, 2-mercaptobenzaldehydes, β-substituted-β-CF3 enones, 2-CF3-thiochromans, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAldol, Aldol, Cascade reaction, Michael, Michael Addition Hydrophosphonylation, imines, phosphite esters, a-amino phosphonates, (8α,9R)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinine DerivativeHydrophosphonylation Vinylogous Michael addition, 3–alkylideneoxindole, 4‐oxo‐enoates, tert-butyl (S,E)-3-(5-(3-bromophenyl)-3-(ethoxycarbonyl)-5-oxo-1-phenylpentylidene)-2-oxoindoline-1-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael Addition, Vinylogous Michael Addition Cascade reaction, 1,4-dithiane-2,5-diol, en-ynones, tetrahydrothiophenes, 3-[(2-Fluorophenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeAldol, Aldol, Cascade reaction, Michael Addition, Sulfa-Michael Cyclization, hydroxymaleimides, ortho-hydroxyphenyl para-quinone, substituted (3aS,9S,9aR)-9-(3,5-di-tert-butyl-4-hydroxyphenyl)-3a-hydroxy-9,9a-dihydrochromeno[2,3-c]pyrrole-1,3(2H,3aH)-dione, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [(8α,9S)-cinchonan-9-ylamino]- 3-Cyclobutene-1,2-dione, Cinchonidine Derivative[4+2] Annulation, [4+2]-Cycloaddition, Cyclization, Cycloaddition, Further Cyclizations Spirocyclization, methyl (5E)-4,5-dihydro-1,2-dimethyl-4-oxo-5-(phenylmethylene)-1H-pyrrole-3-carboxylate, 1,4-dithiane-2,5-diol, methyl (5S,6R,9S)-9-hydroxy-1,2-dimethyl-4-oxo-6-phenyl-7-thia-1-azaspiro[4.4]non-2-ene-3-carboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Cascade reaction, diethyl 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate, tert-butyl (Z)-2-(3,5-dimethylphenyl)-3-nitroacrylate, 2-(tert-butyl) 4-ethyl (S)-2-(3,5-dimethylphenyl)-3-nitro-2,5-dihydrothiophene-2,4-dicarboxylate, 3-[(3,5-dimethylphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Michael Addition, 1-Methyl-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 1-(3-Methylphenyl)-2-propen-1-one, (5R)-1-Methyl-5-[3-(3-methylphenyl)-3-oxopropyl]-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 3-[[3-[bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl]-5-(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Heteroannulation, dinaphtho[2,1-b:1′,2′-d]furan-2-ol, (Z)-1-(2-chloro-2-nitrovinyl)-4-(trifluoromethyl)benzene, dioxa[6]helicenes, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Heteroannulation Mannich reaction, 4-methoxy-6-methylpyrimidin-2-amine, malonic acid esters, aldehydes, amino-pyrimidine derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich« Older EntriesNext Entries »
Cascade reaction, 2-mercaptobenzaldehydes, β-substituted-β-CF3 enones, 2-CF3-thiochromans, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAldol, Aldol, Cascade reaction, Michael, Michael Addition
Hydrophosphonylation, imines, phosphite esters, a-amino phosphonates, (8α,9R)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinine DerivativeHydrophosphonylation
Vinylogous Michael addition, 3–alkylideneoxindole, 4‐oxo‐enoates, tert-butyl (S,E)-3-(5-(3-bromophenyl)-3-(ethoxycarbonyl)-5-oxo-1-phenylpentylidene)-2-oxoindoline-1-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael Addition, Vinylogous Michael Addition
Cascade reaction, 1,4-dithiane-2,5-diol, en-ynones, tetrahydrothiophenes, 3-[(2-Fluorophenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeAldol, Aldol, Cascade reaction, Michael Addition, Sulfa-Michael
Cyclization, hydroxymaleimides, ortho-hydroxyphenyl para-quinone, substituted (3aS,9S,9aR)-9-(3,5-di-tert-butyl-4-hydroxyphenyl)-3a-hydroxy-9,9a-dihydrochromeno[2,3-c]pyrrole-1,3(2H,3aH)-dione, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [(8α,9S)-cinchonan-9-ylamino]- 3-Cyclobutene-1,2-dione, Cinchonidine Derivative[4+2] Annulation, [4+2]-Cycloaddition, Cyclization, Cycloaddition, Further Cyclizations
Spirocyclization, methyl (5E)-4,5-dihydro-1,2-dimethyl-4-oxo-5-(phenylmethylene)-1H-pyrrole-3-carboxylate, 1,4-dithiane-2,5-diol, methyl (5S,6R,9S)-9-hydroxy-1,2-dimethyl-4-oxo-6-phenyl-7-thia-1-azaspiro[4.4]non-2-ene-3-carboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Cascade reaction, diethyl 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate, tert-butyl (Z)-2-(3,5-dimethylphenyl)-3-nitroacrylate, 2-(tert-butyl) 4-ethyl (S)-2-(3,5-dimethylphenyl)-3-nitro-2,5-dihydrothiophene-2,4-dicarboxylate, 3-[(3,5-dimethylphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Michael Addition, 1-Methyl-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 1-(3-Methylphenyl)-2-propen-1-one, (5R)-1-Methyl-5-[3-(3-methylphenyl)-3-oxopropyl]-5-(phenylmethyl)-2-[(phenylmethyl)thio]-4,6(1H,5H)-pyrimidinedione, 3-[[3-[bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl]-5-(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Heteroannulation, dinaphtho[2,1-b:1′,2′-d]furan-2-ol, (Z)-1-(2-chloro-2-nitrovinyl)-4-(trifluoromethyl)benzene, dioxa[6]helicenes, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Heteroannulation
Mannich reaction, 4-methoxy-6-methylpyrimidin-2-amine, malonic acid esters, aldehydes, amino-pyrimidine derivatives, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
