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Cyclization, 2-formylbenzonitrile, diisopropyl malonate, 3-substituted isoindolinones, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Cyclization, Cyclization, Further Cyclizations

Michael Addition, azlactones, o-hydroxy chalcones, (R)-2-((S)-1-(5-chloro-2-hydroxyphenyl)-3-(4-iodophenyl)-3-oxopropyl)-2,4-diphenyloxazol-5(2H)-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Michael, Michael Addition

Michael Addition, acetylaceton, β-nitrostyrene, 3-(2-nitro-1-phenylethyl)pentane-2,4-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Michael, Michael Addition

Alkylation, N-protected 3-allylindolin-2-one, N-protected 1-ethoxy-3-phenylprop-2-yn-1-amine, pyrazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Alkylation, Alkylation

Mannich reaction, substituted 3-iminoindolin-2-one, substituted 2,4-dihydro-3H-pyrazol-3-one, pyrazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Mannich, Mannich

Cyclization, (E)-N-(4-methoxybenzylidene)-4-methylbenzenesulfonamide, isocyanatomalonate diester, 2-imidazolidinones, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Cyclization, Cyclization, Further Cyclizations, Mannich, Mannich

Michael Addition, pyrazoleamides, β-phthalimidonitroethene, 2-((2R,3S)-1-nitro-4-oxo-3-phenyl-4-(1H-pyrazol-1-yl)butan-2-yl)isoindoline-1,3-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Michael, Michael Addition

Spirocyclization, (E)-1,5-dimethyl-3-(2-oxo-2-phenylethylidene)indolin-2-one, 3-isothiocyanato-1-methylindolin-2-one, bispirooxindoles, N-[(1R)-2′-amino[1,1′-binaphthalen]-2-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine Derivative

Michael, Michael Addition, Spirocyclization

Strecker Reaction, cyclic (Z)-aldimines, ethyl carbonocyanidate, (S)-spiro[cyclohexane-1,3′-indoline]-2′-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Strecker

Michael Addition, 2-imino-2H-chromene-3-carbonitrile, diisopropyl malonate, 2-amino-3-nitrile-chromenes, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative

Michael, Michael Addition

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