Mannich reaction, isatin derived N-boc ketimines, 1,3-diketones, 3-amino-oxindoles, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Michael Addition, 1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, 2-chloroacrylonitrile, (S)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, (R)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition Biginelli reaction, aldehydes, thiourea, 4-methyl-3-oxopentanoic acid esters, 6-isopropyl-3,4-dihydropyrimidines, (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions Michael Addition, (E)-nitro olefins, ketones, carbamates, tetrahydroacridines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition 1,3-dipolar Cycloaddition, (Z)-2,4-Dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-3H-pyrazol-3-one, (E)-Dihydro-3-[(2-thienylmethylene)amino]-2(3H)-furanone, (5S,6R,7R,13R)-4-Methyl-2,6-diphenyl-13-(2-thienyl)-9-oxa-2,3,12-triazadispiro[4.1.4.2]tridec-3-ene-1,8-dione, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative1,3-Dipolar Cycloaddition, Cycloaddition, Spirocyclization Desymmetrization, 4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol, (R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization Aza-Mannich Addition, 2-(ethylthio)thiazol-5(4H)-ones, substituted 4-methyl-N-methylenebenzenesulfonamide, modified chiral 2-(ethylthio)-thiazolone derivatives, (8α,9R)-6′-Methoxy-9-[(trimethylsilyl)oxy]cinchonan, Quinine DerivativeAza-Mannich, Mannich Bromolactonization, (Z)-2-(pent-2-en-4-yn-1-yloxy)benzoic acids, N-Bromosuccinimide, (S)-3-(4-bromo-3l5-buta-2,3-dien-1-yl)-2,3-dihydro-5H-benzo[e][1,4]dioxepin-5-ones, N-[[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]carbonyl]-4-methylbenzenesulfonamide, Quinine DerivativeBromination, Lactonization Cascade reaction, (E)-1-nitrohex-1-ene, (E)-7-oxo-7-phenylhept-5-enal, (1S,2S,3S,4S)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexane-1-carbaldehyde, D-Proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction Aza-Henry (Nitro-Mannich), imines, nitroethane, β-nitro amines, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich« Older EntriesNext Entries »
Mannich reaction, isatin derived N-boc ketimines, 1,3-diketones, 3-amino-oxindoles, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Michael Addition, 1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, 2-chloroacrylonitrile, (S)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, (R)-2-((S)-2-chloro-2-cyanoethyl)-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition
Biginelli reaction, aldehydes, thiourea, 4-methyl-3-oxopentanoic acid esters, 6-isopropyl-3,4-dihydropyrimidines, (1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions
Michael Addition, (E)-nitro olefins, ketones, carbamates, tetrahydroacridines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition
1,3-dipolar Cycloaddition, (Z)-2,4-Dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-3H-pyrazol-3-one, (E)-Dihydro-3-[(2-thienylmethylene)amino]-2(3H)-furanone, (5S,6R,7R,13R)-4-Methyl-2,6-diphenyl-13-(2-thienyl)-9-oxa-2,3,12-triazadispiro[4.1.4.2]tridec-3-ene-1,8-dione, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative1,3-Dipolar Cycloaddition, Cycloaddition, Spirocyclization
Desymmetrization, 4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol, (R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization
Aza-Mannich Addition, 2-(ethylthio)thiazol-5(4H)-ones, substituted 4-methyl-N-methylenebenzenesulfonamide, modified chiral 2-(ethylthio)-thiazolone derivatives, (8α,9R)-6′-Methoxy-9-[(trimethylsilyl)oxy]cinchonan, Quinine DerivativeAza-Mannich, Mannich
Bromolactonization, (Z)-2-(pent-2-en-4-yn-1-yloxy)benzoic acids, N-Bromosuccinimide, (S)-3-(4-bromo-3l5-buta-2,3-dien-1-yl)-2,3-dihydro-5H-benzo[e][1,4]dioxepin-5-ones, N-[[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]carbonyl]-4-methylbenzenesulfonamide, Quinine DerivativeBromination, Lactonization
Cascade reaction, (E)-1-nitrohex-1-ene, (E)-7-oxo-7-phenylhept-5-enal, (1S,2S,3S,4S)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexane-1-carbaldehyde, D-Proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction
Aza-Henry (Nitro-Mannich), imines, nitroethane, β-nitro amines, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
