Aza-Michael Addition, o-N-tosylaminophenyl α,β-unsaturated ketones, α-nitroalkenes, chiral tetrahydroquinolines, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeAza-Michael, Michael Addition Alkylation, pyrazolones, propargyl bromide, (S)-4-benzyl-2,5-diphenyl-4-(prop-2-yn-1-yl)-2,4-dihydro-3H-pyrazol-3-one, (1S,2R,4S,5R)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-1-(2-(((4-methoxyphenyl)diphenylmethyl)amino)-2-oxoethyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeAlkylation, Alkynylation Michael Addition, maleimides, ketones, substituted (R)-2-(2,5-dioxopyrrolidin-3-yl)acetaldehyde, (S)-2-amino-2-(2-chlorophenyl)acetic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition Strecker Synthesis, N-(4-nitrobenzyl)-3-phenylpropanimidoyl cyanide, (E)-but-2-enal, α,α-dialkyl aminonitriles, 9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-6′-methoxy-cinchonanium bromide, Quinidine DerivativeStrecker Michael Addition, 4-methoxybenzyl 2-bromo-3-(ethylthio)-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3R)-2-bromo-2-((ethylthio)carbonyl)-4-nitro-3-phenylbutanoate, S-ethyl (1R,2R,3R)-2-nitro-3-phenylcyclopropane-1-carbothioate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeCyclopropanation, Michael, Michael Addition Spirocyclization, 1-benzyl-5-bromoindoline-2,3-dione, malononitrile, benzo[d][1,3]dioxol-5-ol, spiro[4H-chromene-3,3′-oxindoles], 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeCascade reaction, Spirocyclization Vinylogous Michael addition, β-acyl acrylates, 1,2-diacylethylenes, α,β-unsaturated γ-butyrolactam, substituted (R)-2-((R)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)succinaldehyde, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael Addition, Vinylogous Michael Addition Spirocyclization, isatins, γ-hydroxy enones, cyclic acetals with spirooxindole skeleton, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization Peroxidation, α,β-unsaturated aldehydes, peroxides, β-peroxid aldehydes, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeFurther reactions, Peroxidation Decarboxylative Protonation, substituted meldrum’s acid, tert-butyl hydroxy((phenylsulfonyl)methyl)carbamate, tert-butyl (R)-4-benzyl-5-oxoisoxazolidine-2-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeDecarboxylative Protonation, Protonation« Older EntriesNext Entries »
Aza-Michael Addition, o-N-tosylaminophenyl α,β-unsaturated ketones, α-nitroalkenes, chiral tetrahydroquinolines, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeAza-Michael, Michael Addition
Alkylation, pyrazolones, propargyl bromide, (S)-4-benzyl-2,5-diphenyl-4-(prop-2-yn-1-yl)-2,4-dihydro-3H-pyrazol-3-one, (1S,2R,4S,5R)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-1-(2-(((4-methoxyphenyl)diphenylmethyl)amino)-2-oxoethyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeAlkylation, Alkynylation
Michael Addition, maleimides, ketones, substituted (R)-2-(2,5-dioxopyrrolidin-3-yl)acetaldehyde, (S)-2-amino-2-(2-chlorophenyl)acetic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael, Michael Addition
Strecker Synthesis, N-(4-nitrobenzyl)-3-phenylpropanimidoyl cyanide, (E)-but-2-enal, α,α-dialkyl aminonitriles, 9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)-3,3′′,4,4′′,5,5′′-hexamethoxy[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-6′-methoxy-cinchonanium bromide, Quinidine DerivativeStrecker
Michael Addition, 4-methoxybenzyl 2-bromo-3-(ethylthio)-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3R)-2-bromo-2-((ethylthio)carbonyl)-4-nitro-3-phenylbutanoate, S-ethyl (1R,2R,3R)-2-nitro-3-phenylcyclopropane-1-carbothioate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinidine DerivativeCyclopropanation, Michael, Michael Addition
Spirocyclization, 1-benzyl-5-bromoindoline-2,3-dione, malononitrile, benzo[d][1,3]dioxol-5-ol, spiro[4H-chromene-3,3′-oxindoles], 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeCascade reaction, Spirocyclization
Vinylogous Michael addition, β-acyl acrylates, 1,2-diacylethylenes, α,β-unsaturated γ-butyrolactam, substituted (R)-2-((R)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)succinaldehyde, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeMichael Addition, Vinylogous Michael Addition
Spirocyclization, isatins, γ-hydroxy enones, cyclic acetals with spirooxindole skeleton, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization
Peroxidation, α,β-unsaturated aldehydes, peroxides, β-peroxid aldehydes, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeFurther reactions, Peroxidation
Decarboxylative Protonation, substituted meldrum’s acid, tert-butyl hydroxy((phenylsulfonyl)methyl)carbamate, tert-butyl (R)-4-benzyl-5-oxoisoxazolidine-2-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeDecarboxylative Protonation, Protonation
