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Vinylogous Michael Addition, chalcones, α,α-Dicyanoolefins, α,α-Dicyanoolefins chalcone michael adducts, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivative

Michael Addition, Vinylogous Michael Addition

Cascade reaction, thiophenols, imines, chalcones, N-[(1S,2R,3S)-2-Benzoyl-3-[[4-(1,1-dimethylethyl)phenyl]thio]-1-(4-fluorophenyl)-3-(4-methylphenyl)propyl]-4-methylbenzenesulfonamide, (8α,9R)-1-[(2-nitrophenyl)methyl]-9-(2-propen-1-yloxy)- 6′-(4-propylphenyl)-cinchonanium bromide, Quinine Derivative

Cascade reaction

Oxa-Michael, substituted 2-(2-vinylcyclopropyl)phenol, ethyl (1S,1aS,2R,7bR)-2-(2-ethoxy-2-oxoethyl)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-1-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′- methoxycinchonan-9-yl]thiourea, Quinidine Derivative

Michael Addition, Oxa-Michael Addition

Cyclopropanation, 4-nitro-5-styrylisoxazoles, bromomethylene diacetate, substituted (R)-2-(3-methyl-4-nitroisoxazol-5-yl)cyclopropane-1,1-diyl diacetate, (9S)-9-hydroxy-6′-methoxy-1-[(2-methoxyphenyl)methyl]-cinchonanium bromide, Quinidine Derivative

Cyclopropanation

Cascade reaction, ethyl (E)-4-mercaptobut-2-enoate, 3-nitrobenzothiophene, tetrahydrothiophenebenzothiophene, (αR)-α-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzenepropanamide, Quinine Derivative

Cascade reaction, Michael, Michael Addition

Umpolung, substituted 2,2,2-trifluoroethan-1-imine, α,β-unsaturated lactones, trifluoromethylated γ-amino lactones, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-6′-methoxy-cinchonanium bromide, Quinidine Derivative

Umpolung

Spirocyclization, (Z)-2-benzylidenebenzofuran-3(2H)-one, cyclopent-2-en-1-one, (1’R,2R,3’R,4’R)-3′-phenyl-3H-spiro[benzofuran-2,2′-bicyclo[2.2.1]heptane]-3,5′-dione, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine Derivative

[4+2]-Cycloaddition, Cycloaddition, Diels-Alder reaction, Spirocyclization

Bromination, 2-naphthols, N-bromophthalimide, substituted isopropyl (1R)-1-bromo-2-hydroxy-1,2-dihydronaphthalene-1-carboxylate, (9S)-9-[(4-chloro-1-phthalazinyl)oxy]-6′-methoxy-cinchonan, Quinidine Derivative

Bromination, Dearomatization, Further reactions

Amination, (1-bromoethyl)benzene, S,S-diphenylsulfoximine, (αR)-α-Methyl-N-(oxidodiphenyl-λ4-sulfanylidene)benzenemethanamine, (2-thiophenecarboxylato-κO2,κS1)-copper, 2-[bis[3,3′′,5,5′′-tetrakis(1,1-dimethylethyl)[1,1′:3′,1′′-terphenyl]-5′-yl]phosphino]-N-[(8α,9R)-6′-methoxycinchonan-9-yl]-benzamide, Quinidine Derivative

Amination

Spirocyclization, indoles, spirocyclic compouns, (1S,2R,4S,5R)-1-(2-bromo-5-methoxybenzyl)-2-((S)-(1-(2-bromo-5-methoxybenzyl)-6-methoxyquinolin-1-ium-4-yl)(hydroxy)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine Derivative

Spirocyclization

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