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Alkylation, pyrazolones, alkyl halides, pyrazolones, (9S)-9-hydroxy-6′-methoxy-1-[2-oxo-2-[(triphenylmethyl)amino]ethyl]-cinchonanium bromide, Quinidine Derivative

Alkylation, alpha-Alkylation

Cycloaddition, azlactones, C,N‐cyclic azomethine imines, tricyclic tetrahydroisoquinolines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine Derivative

1,3-Dipolar Cycloaddition, Cycloaddition

Knoevenagel Condensation, 4-substituted cyclohexan-1-one, oxindoles, alkylideneoxindoles, 3,5-dinitrobenzoic acid, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine Derivative

Knoevenagel

Sulfa-Michael Addition, acyclic 2‐en‐4‐ynones, phenylmethanethiol, 3-(benzylthio)-1,5-diphenylpent-4-yn-1-one, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine Derivative

Michael Addition, Sulfa-Michael, Sulfa-Michael Addition

Desymmetrization, 4,6-bis(benzyloxy)cyclohexane-1,2,3,5-tetraol, benzoyl chloride, (1S,2S,3R,4S,5R,6S)-2,4-bis(benzyloxy)-3,5,6-trihydroxycyclohexyl benzoate, (9S)-9-(diphenylphosphinite)6′-methoxy-cinchonan-9-ol, Quinidine Derivative

Desymmetrization

Atropisomer synthesis, 1-(2-hydroxyphenyl)-4,6-diphenylpyridin-2(1H)-one, (iodomethyl)benzene, N-aryl pyridones, (9S)-1-(9-anthracenylmethyl)-9-hydroxy-6′-methoxy-cinchonanium chloride, Quinidine Derivative

Atropisomer synthesis

Cascade reaction, 2-mercaptoquinoline-3-carbaldehydes, nitroolefins, 2H-Thiopyrano[2,3-b]quinolines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Cascade reaction

Spirocyclization, 3-methyl-4-nitro-5-isatylidenyl-isoxazoles, N-2,2,2-trifluoroethylisatin ketimines, isoxazole and trifluoromethyl-containing 3,2′-pyrrolidinyl dispirooxindoles, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine Derivative

Cascade reaction, Spirocyclization

Aza-Friedel-Crafts reaction, indoles, imines, (1H-indol-3-yl)(phenyl)-l3-methanamines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9S)-10,11-dihydro-6′-methoxy-11-[[3-(trihydroxysilyl)propyl]thio]cinchonan-6′-yl]thiourea, Quinine Derivative

Aza-Friedel-Crafts, Friedel-Crafts

Aza-Friedel-Crafts reaction, benzothiazolimines, 2-naphthols, 2′-aminobenzothiazolomethyl naphthols, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Aza-Friedel-Crafts, Friedel-Crafts

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