Mannich reaction, 3-(2-isothiocyanatoacetyl)oxazolidin-2-one, (E)-N-benzylidene-4-bromobenzenesulfonamide, α,β-diamino acid derivatives, (9S)-9-acetate-cinchonan-6′,9-diol, Cupreidine DerivativeMannich, Mannich Vinylogous Michael Addition, maleimides, γ-aryl-substituted deconjugated butenolides, chiral butenolides with adjacent quaternary and tertiary stereocenters, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Vinylogous Michael Addition Cascade reaction, 5-benzylidene-2,2-dimethyl-1,3-dioxane-4,6-dione, diethyl (E)-2-((5-bromo-2-hydroxybenzylidene)amino)malonate, diethyl (3S,3aR,9bS)-8-bromo-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction Spirocyclization, 3-(2-methylallyl)cyclohex-2-en-1-one, (E)-1-methoxy-2-(2-nitrovinyl)benzene, (6S,10R,11R)-10-(2-methoxyphenyl)-8-methyl-11-nitrospiro[5.5]undec-7-en-2-one, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization [3+3]-Annulation, 2-(1-Alkynyl)-2-alken-1-ones, 3-Aminobenzofurans, Polycyclic 1,4-Dihydropyridines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[3+3]-Annulation, Cyclization, Further Cyclizations Cascade reaction, 2-phenyl-N-(quinolin-8-yl)acrylamide, nitromethane, methyl (E)-3-iodoacrylate, methyl 2-((1R,2R,4R)-2-nitro-4-(quinolin-8-ylcarbamoyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Atropisomer Synthesis, 2-naphthalen-imidazoles, 1-(bromomethyl)-pentafluorobenzene, axially chiral imidazoles, (9S)-N-[(3,5-difluorophenyl)methyl]-6′,9-dihydroxy-cinchonanium bromide, Cupreidine DerivativeAtropisomer synthesis, Desymmetrization Spirocyclization, tert-butyl (1-benzyl-2-oxoindolin-3-yl)(2-chloroethyl)carbamate, tert-butyl (S)-1′-benzyl-2′-oxospiro[azetidine-2,3′-indoline]-1-carboxylate, (1S,2S,4S,5R)-2-((R)-hydroxy(quinolin-4-yl)methyl)-1-(4-(pentafluoro-l6-sulfaneyl)benzyl)-5-vinylquinuclidin-1-ium bromide, Cinchonidine DerivativeAlkylation, Spirocyclization Vinylogous Michael Addition, 5-methylfuran-2(3H)-one, tert-butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, tert-butyl (R)-4-((R)-2-methyl-5-oxo-2,5-dihydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael Addition, Vinylogous Michael Addition Nazarov Cyclization, substituted (E)-hepta-4,6-diene-2,3-dione, substituted 5-hydroxy-4-methylenecyclopent-2-en-1-one, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeCyclization, Further Cyclizations, Nazarov cyclization« Older EntriesNext Entries »
Mannich reaction, 3-(2-isothiocyanatoacetyl)oxazolidin-2-one, (E)-N-benzylidene-4-bromobenzenesulfonamide, α,β-diamino acid derivatives, (9S)-9-acetate-cinchonan-6′,9-diol, Cupreidine DerivativeMannich, Mannich
Vinylogous Michael Addition, maleimides, γ-aryl-substituted deconjugated butenolides, chiral butenolides with adjacent quaternary and tertiary stereocenters, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Vinylogous Michael Addition
Cascade reaction, 5-benzylidene-2,2-dimethyl-1,3-dioxane-4,6-dione, diethyl (E)-2-((5-bromo-2-hydroxybenzylidene)amino)malonate, diethyl (3S,3aR,9bS)-8-bromo-4-oxo-3-phenyl-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction
Spirocyclization, 3-(2-methylallyl)cyclohex-2-en-1-one, (E)-1-methoxy-2-(2-nitrovinyl)benzene, (6S,10R,11R)-10-(2-methoxyphenyl)-8-methyl-11-nitrospiro[5.5]undec-7-en-2-one, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization
[3+3]-Annulation, 2-(1-Alkynyl)-2-alken-1-ones, 3-Aminobenzofurans, Polycyclic 1,4-Dihydropyridines, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[3+3]-Annulation, Cyclization, Further Cyclizations
Cascade reaction, 2-phenyl-N-(quinolin-8-yl)acrylamide, nitromethane, methyl (E)-3-iodoacrylate, methyl 2-((1R,2R,4R)-2-nitro-4-(quinolin-8-ylcarbamoyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Atropisomer Synthesis, 2-naphthalen-imidazoles, 1-(bromomethyl)-pentafluorobenzene, axially chiral imidazoles, (9S)-N-[(3,5-difluorophenyl)methyl]-6′,9-dihydroxy-cinchonanium bromide, Cupreidine DerivativeAtropisomer synthesis, Desymmetrization
Spirocyclization, tert-butyl (1-benzyl-2-oxoindolin-3-yl)(2-chloroethyl)carbamate, tert-butyl (S)-1′-benzyl-2′-oxospiro[azetidine-2,3′-indoline]-1-carboxylate, (1S,2S,4S,5R)-2-((R)-hydroxy(quinolin-4-yl)methyl)-1-(4-(pentafluoro-l6-sulfaneyl)benzyl)-5-vinylquinuclidin-1-ium bromide, Cinchonidine DerivativeAlkylation, Spirocyclization
Vinylogous Michael Addition, 5-methylfuran-2(3H)-one, tert-butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate, tert-butyl (R)-4-((R)-2-methyl-5-oxo-2,5-dihydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeMichael Addition, Vinylogous Michael Addition
Nazarov Cyclization, substituted (E)-hepta-4,6-diene-2,3-dione, substituted 5-hydroxy-4-methylenecyclopent-2-en-1-one, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol, Dihydrocupreidine DerivativeCyclization, Further Cyclizations, Nazarov cyclization
