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Spirocyclization, oxindoles, (E)-3-styrylcyclohex-2-en-1-one, spirocyclic oxindoles, (9R)-9-Aminocinchonan-6′-ol, Cupreidine Derivative

Spirocyclization

Isomerization, 5-methylfuran-2(3H)-one, (R)-5-methylfuran-2(5H)-one, (9S)-1-[[3,5-bis(triethylsilyl)phenyl]methyl]-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-6′-hydroxy-cinchonanium bromide, Cupreidine Derivative

Isomerization

Addition, α-ketoesters, nitromethane, 2-substitued ethyl 2-hydroxy-3-nitropropanoate, (9S)-cinchonan-6′,9-diol-9-benzoate, Cupreidine Derivative

Addition, Aldol, Henry, Henry, Nitroaldol

Umpolung, trifluoromethylketimines, α,β-unsaturated ketones, trifluoromethylated γ-amino esters, (9S)-1-(9-anthracenylmethyl)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-6′-(1-methylethoxy)-cinchonanium bromide, Cupreidine Derivative

Umpolung

Isomerization, cyanoketimines, α‐tertiary aminonitriles, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-cinchonan-6′-ol, Cupreidine Derivative

Isomerization

Fluorination, α-branched enals, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, (R,E)-2-fluoro-2-methyl-4-(p-tolyl)but-3-enal, (9R)-9-Aminocinchonan-6′-ol, Cupreidine Derivative

alpha-Fluorination, Fluorination

Peroxidation, (E)-(4-((trifluoromethyl)sulfonyl)but-3-en-1-yl)benzene, (2-hydroperoxypropan-2-yl)benzene, (S)-(2-((4-phenyl-1-((trifluoromethyl)sulfonyl)butan-2-yl)peroxy)propan-2-yl)benzene, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1- [[2′-(1,1-dimethylethoxy)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]- 6′-hydroxy-Cinchonanium inner salt, Cupreidine Derivative

Further reactions, Kinetic resolution, Peroxidation, Resolution

Spirocyclization, substituted 3-aminocyclohex-2-en-1-one, substituted indoline-2,3-dione, malononitrile, tetrahydroquinolin-5-one-based spirooxindoles, (9R)-inchonan-6′,9-diol, Cupreidine Derivative

Spirocyclization

Desymmetrization, (1R,4S,7S,8R)-7,8-bis((benzyloxy)methyl)-2,3-dioxabicyclo[2.2.2]oct-5-ene, γ-hydroxyenones, (9S)-9-acetate-cinchonan-6′,9-diol, Cupreidine Derivative

Desymmetrization

Henry reaction, 4-(trifluoromethyl)benzaldehyde, nitroethane, 2-nitro-1-(4-(trifluoromethyl)phenyl)propan-1-ol, (9S)-9-(phenylmethoxy)-cinchonan-6′-ol, Cupreidine Derivative

Henry, Henry

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