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Desymmetrization of anhydrides, cyclic anhydrides, methanol, methyl monoesters, Quinine Base

Desymmetrization

alpha-Arylation of cycloketones, cycloketones, aryl halides, alpha-aryl cycloketones, Palladium(0)-bis(dibenzylidenaceton), Quinine Base

Arylation, Further reactions

Aza-Henry (Nitro-Mannich), ethyl (E)-2-((4-methoxyphenyl)imino)acetate, tert-butyl 2-nitropropanoate, 1-(tert-butyl) 4-ethyl (2S,3R)-3-((4-methoxyphenyl)amino)-2-methyl-2-nitrosuccinate, Quinine Base

Aza-Henry, Henry, Mannich, Nitro-Mannich

Henry reaction (Nitroaldol), aromatic or aliphatic aldehydes, alpha substituted nitromethane, beta-nitroalcohols, copper (II) acetate, Quinine Base

Aldol, Henry, Henry, Nitroaldol

Protonation of alpha-oxygenated ester enolates, alpha-ketoesters, phosphites, alpha-phosphonyloxy esters, Quinine Base

Protonation

Spirocyclization/Domino Mannich/Cyclization, 3-isothiocyanato oxindoles, imines, spirocyclic oxindoles, Quinine Base

Cascade reaction, Spirocyclization

alpha-Amination of 5-substituted rhodanines, 5-substituted rhodanines, diethyl (E)-diazene-1,2-dicarboxylate, diethyl 1-(5-substituted-4-oxo-2-thioxothiazolidin-5-yl)hydrazine-1,2-dicarboxylate, Quinine Base

alpha-Amination, Amination, Further reactions

Strecker reaction, alpha‐amido sulfones, cyanopotassium, N‐arylsulfonyl alpha‐amino nitriles, Quinine Base

Strecker

Hydroxylation of 4-substituted Pyrazolones, 4,5-substituted-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, (2-hydroperoxypropan-2-yl)benzene, 4,5-substituted-4-hydroxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, Quinine Base

Hydroxylation

Allylic Alkylation, Morita-Baylis-Hillman Carbonates, N-(2-formylphenyl)-4-methylbenzenesulfonamide, diethyl 2-aminomalonate, 1,1-diethyl 3-methyl (S,E)-2-substituted-1-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)but-3-ene-1,1,3-tricarboxylate, Quinine Base

Alkylation, Allylic Alkylation

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