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Henry reaction (Nitroaldol), trifluoromethyl ketones, nitromethane, substituted 1,1,1-trifluoro-3-nitropropan-2-ol, (8α,9R)-Cinchonan-6′,9-diol 9-[3,5-bis(trifluoromethyl)benzoate], Cupreine Derivative

Aldol, Henry, Henry, Nitroaldol

Henry reaction (Nitroaldol), alpha-ketoester, nitromethane, alpha-hydroxy-alpha-(nitromethyl)ester, (8α,9R)-Cinchonan-6′,9-diol-9-benzoate, Cupreine Derivative

Aldol, Henry, Henry, Nitroaldol

Aza-Henry – Nitro-Mannich spirocyclization, isatin-derived ketimines, nitroalkane mesylates, spiro-pyrrolidine/piperidine-oxindoles, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivative

Spirocyclization

Henry reaction (Nitroaldol), isatins, nitroalkanes, substituted 3-hydroxy-3-(nitromethyl)indolin-2-one, Cupreine Base

Aldol, Henry, Henry, Nitroaldol

Henry with alpha-ketophosphonate, alpha-ketophosphonates, nitromethane, (1-hydroxy-2-nitroethyl)phosphonates, Cupreine Base

Henry, Henry

Michael Addition – annulation sequence, 2-(phenylethynyl)cyclohex-2-en-1-one, 2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one, (S)-5-benzyl-1,3-diphenyl-7,8,9,9a-tetrahydroisochromeno[3,4-c]pyrazol-6(3H)-one, (8α,9R)-6′-[[Tris(1-methylethyl)silyl]oxy]cinchonan-9-ol, Cupreine Derivative

Cascade reaction, Cyclization

Michael Addition, nitroolfins, nitroalkanes, substituted dinitroalkanes, (8α,9R)-Cinchonan-6′,9-diol 9-acetate, Cupreine Derivative

Michael, Michael Addition

Sulfa-Michael/Michael Addition, nitroolefins, ethyl (E)-3-(2-mercaptophenyl)acrylate, thiochroman derivatives, (8α,9R)-6′-(1-Methylethoxy)cinchonan-9-ol, Cupreine Derivative

Michael, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition

Michael Addition, indolylnitroalkenes, malonates, 3-(2-nitro-1-(1-tosyl-1H-indol-3-yl) ethyl) pentane-2,4-dione derivatives, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivative

Michael, Michael Addition

Michael Addition, nitrodienes, beta-ketoesters, substituted 1-(2-nitro-1-substituted-ethyl)-2-oxocyclopentane-1-carboxylate, (8α,9R)-9-(Phenylmethoxy) cinchonan-6′-ol, Cupreine Derivative

Michael, Michael Addition

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