Cross-Mannich, N/C-substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, N/C-substituted tert-butyl ((3S,3’R)-2,2′-dioxo-3-(((E)-2,2,2-trifluoroethylidene)amino)-[3,3′-biindolin]-3′-yl)carbamate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMannich Cross-coupling, 1-(1-bromopropyl)-3-methoxybenzene, (E)-4,4,6-trimethyl-2-styryl-1,3,2-dioxaborinane, (S,E)-1-methoxy-3-(1-phenylpent-1-en-3-yl)benzene, copper(I) iodide, N-[(9S)-6′-methoxycinchonan-9-yl]-2-methyl-8-quinolinesulfonamide, Quinine DerivativeCross Coupling Cross-coupling, 2-methyl-2,3-dihydro-1H-inden-1-one, aryl halides, 2-substituted (R)-2-methyl-2,3-dihydro-1H-inden-1-one, tris(dibenzylideneacetone)dipalladium(0), Quinine BaseCross Coupling Sulfa-Michael Mannich cascade, arylic thiols, arylic (E)-nitroethene, arylic (E)-4-methyl-N-methylenebenzenesulfonamide, 1,3 substituted N-((1R,2S,3S)-3-(arylthio)-2-nitropropyl)-4-methylbenzenesulfonamide, N-[(1R,2S)-2-(1,1-dimethylethoxy)-1-[[[[[(8α,9R)-9-(phenylmethoxy)cinchonan-6′-yl]amino]thioxomethyl]amino]methyl]propyl]-4-methyl-benzenesulfonamide, 6´-Aminocinchonidine DerivativeCascade reaction, Mannich, Mannich, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition Michael addition, 5-methyl-2-(quinolin-2-yl)thiazol-4(5H)-one, (E)-(2-nitrovinyl)benzene, (R)-5-methyl-5-((S)-2-nitro-1-phenylethyl)-2-(quinolin-2-yl)thiazol-4(5H)-one, 9-Anthracenylmethyl N-[(1S)-1-[[[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Dihydroquinine DerivativeMichael, Michael Addition Michael Addition, 2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)ethan-1-one, (E)-(2-nitrovinyl)benzene, (2R,3S)-4-nitro-2-(4-nitrophenyl)-3-phenyl-1-(1H-pyrazol-1-yl)butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeMichael, Michael Addition Aldol reaction, 3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one, paraformaldehyde, (S)-3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-3-(hydroxymethyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one, N-[3,5-bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeAldol, Aldol Fluorination, tert-butyl 2-oxo-3-phenylindoline-1-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, tert-butyl (R)-3-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 1,4-bis[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-9,10-Anthracenedione, Dihydroquinine DerivativeFluorination, Fluorination Fluorodesilylation, ((2-(4-chlorobenzyl)-1H-inden-3-yl)methyl)trimethylsilane, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, (R)-2-(4-chlorobenzyl)-2-fluoro-1-methylene-2,3-dihydro-1H-indene, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]-bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeFluorination, Fluorination Mannich reaction, methyl 2-fluoro-3-((2-fluorophenyl)thio)-3-oxopropanoate, tert-butyl (E)-benzylidenecarbamate, methyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-fluoro-2-(((2-fluorophenyl)thio)carbonyl)-3-phenylpropanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich« Older EntriesNext Entries »
Cross-Mannich, N/C-substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, N/C-substituted tert-butyl ((3S,3’R)-2,2′-dioxo-3-(((E)-2,2,2-trifluoroethylidene)amino)-[3,3′-biindolin]-3′-yl)carbamate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMannich
Cross-coupling, 1-(1-bromopropyl)-3-methoxybenzene, (E)-4,4,6-trimethyl-2-styryl-1,3,2-dioxaborinane, (S,E)-1-methoxy-3-(1-phenylpent-1-en-3-yl)benzene, copper(I) iodide, N-[(9S)-6′-methoxycinchonan-9-yl]-2-methyl-8-quinolinesulfonamide, Quinine DerivativeCross Coupling
Cross-coupling, 2-methyl-2,3-dihydro-1H-inden-1-one, aryl halides, 2-substituted (R)-2-methyl-2,3-dihydro-1H-inden-1-one, tris(dibenzylideneacetone)dipalladium(0), Quinine BaseCross Coupling
Sulfa-Michael Mannich cascade, arylic thiols, arylic (E)-nitroethene, arylic (E)-4-methyl-N-methylenebenzenesulfonamide, 1,3 substituted N-((1R,2S,3S)-3-(arylthio)-2-nitropropyl)-4-methylbenzenesulfonamide, N-[(1R,2S)-2-(1,1-dimethylethoxy)-1-[[[[[(8α,9R)-9-(phenylmethoxy)cinchonan-6′-yl]amino]thioxomethyl]amino]methyl]propyl]-4-methyl-benzenesulfonamide, 6´-Aminocinchonidine DerivativeCascade reaction, Mannich, Mannich, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition
Michael addition, 5-methyl-2-(quinolin-2-yl)thiazol-4(5H)-one, (E)-(2-nitrovinyl)benzene, (R)-5-methyl-5-((S)-2-nitro-1-phenylethyl)-2-(quinolin-2-yl)thiazol-4(5H)-one, 9-Anthracenylmethyl N-[(1S)-1-[[[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Dihydroquinine DerivativeMichael, Michael Addition
Michael Addition, 2-(4-nitrophenyl)-1-(1H-pyrazol-1-yl)ethan-1-one, (E)-(2-nitrovinyl)benzene, (2R,3S)-4-nitro-2-(4-nitrophenyl)-3-phenyl-1-(1H-pyrazol-1-yl)butan-1-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeMichael, Michael Addition
Aldol reaction, 3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one, paraformaldehyde, (S)-3-(6-((tert-butyldimethylsilyl)oxy)benzo[d][1,3]dioxol-5-yl)-3-(hydroxymethyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one, N-[3,5-bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeAldol, Aldol
Fluorination, tert-butyl 2-oxo-3-phenylindoline-1-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, tert-butyl (R)-3-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 1,4-bis[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-9,10-Anthracenedione, Dihydroquinine DerivativeFluorination, Fluorination
Fluorodesilylation, ((2-(4-chlorobenzyl)-1H-inden-3-yl)methyl)trimethylsilane, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, (R)-2-(4-chlorobenzyl)-2-fluoro-1-methylene-2,3-dihydro-1H-indene, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]-bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeFluorination, Fluorination
Mannich reaction, methyl 2-fluoro-3-((2-fluorophenyl)thio)-3-oxopropanoate, tert-butyl (E)-benzylidenecarbamate, methyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-fluoro-2-(((2-fluorophenyl)thio)carbonyl)-3-phenylpropanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich
