Spirocyclization, substituted ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, 1,4-dithiane-2,5-diol, substituted ethyl (2’S,3R,4’R)-4′-hydroxy-1-methyl-2-oxo-4′,5′-dihydro-2’H-spiro[indoline-3,3′-thiophene]-2′-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3- cyclobutene-1,2-dione, Cinchonine DerivativeAldol, Aldol, Cyclization, Michael Addition, Spirocyclization, Sulfa-Michael, Sulfa-Michael Addition Mannich reaction, dicarbonyls, alpha-amido sulfones, substituted N-(2-formyl-3-oxopropyl)formamide, Cinchonine BaseMannich, Mannich Chloro-O-Cyclization, 2-substituted allyl tosylcarbamate, 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione, (S,E)-N-(4-substituted-4-(chloromethyl)-1,3-dioxolan-2-ylidene)-4-methylbenzenesulfonamide, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeChlorination, Cyclization, Further Cyclizations, Intramolecular cyclization Spirocyclization, N/C-substituted 2-(2-oxoindolin-3-ylidene)malononitrile, N/C-Substituted 3-hydroxyindolin-2-one, N/C-subsituted 5′-amino-2,2”-dioxodispiro[indoline-3,2′-furan-3′,3”-indoline]-4′-carbonitrile, Cinchonine BaseCyclization, Michael, Michael Addition, Spirocyclization Amination, ethyl 2-oxocyclopentane-1-carboxylate, dibenzyl (E)-diazene-1,2-dicarboxylate, dibenzyl (R)-1-(1-(ethoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate, Cinchonine BaseAmination Wolff rearrangement, 5-diazo-2,2-dimethylcyclopentan-1-one, quinolin-8-amine, (S)-2,2-dimethyl-N-(quinolin-8-yl)cyclobutane-1-carboxamide, Cinchonine BaseFurther reactions, Rearrangement Oxa-Michael addition, substituted 2-vinylbenzoic acid, substituted (R)-3-methylisobenzofuran-1(3H)-one, Cinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, Lactonization, Michael Addition, Oxa-Michael Addition Dimerization, prop-1-en-1-one, (S,Z)-4-ethylidene-3-methyloxetan-2-one, Quinine Base[2+2]-Cycloaddition, Cycloaddition, Dimerization, Further reactions, Lactonization Spirocyclization, (E)-1-methyl-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted 2-benzylidene-1H-indene-1,3(2H)-dione, (2’R,4’S,5’S)-1”-methyl-4′-phenyl-5′-(trifluoromethyl)dispiro[indene-2,3′-pyrrolidine-2′,3”-indoline]-1,2”,3-trione, Quinine Base[3+2]-Cycloaddition, Cyclization, Spirocyclization Cross-Coupling, tert-butyl 2-oxo-3-phenylindoline-1-carboxylate, (E)-buta-1,3-dien-1-ylbenzene, tert-butyl (R)-2-oxo-3-phenyl-3-((R,E)-4-phenylbut-3-en-2-yl)indoline-1-carboxylate, di-μ-chlorobis(η3-2-propenyl)di-palladium, 4,4′-((3,3′-bis(3,5-bis(trifluoromethyl)phenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-[1,1′-binaphthalene]-2,2′-diyl)bis(oxy))didinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCross Coupling« Older EntriesNext Entries »
Spirocyclization, substituted ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, 1,4-dithiane-2,5-diol, substituted ethyl (2’S,3R,4’R)-4′-hydroxy-1-methyl-2-oxo-4′,5′-dihydro-2’H-spiro[indoline-3,3′-thiophene]-2′-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3- cyclobutene-1,2-dione, Cinchonine DerivativeAldol, Aldol, Cyclization, Michael Addition, Spirocyclization, Sulfa-Michael, Sulfa-Michael Addition
Mannich reaction, dicarbonyls, alpha-amido sulfones, substituted N-(2-formyl-3-oxopropyl)formamide, Cinchonine BaseMannich, Mannich
Chloro-O-Cyclization, 2-substituted allyl tosylcarbamate, 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione, (S,E)-N-(4-substituted-4-(chloromethyl)-1,3-dioxolan-2-ylidene)-4-methylbenzenesulfonamide, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeChlorination, Cyclization, Further Cyclizations, Intramolecular cyclization
Spirocyclization, N/C-substituted 2-(2-oxoindolin-3-ylidene)malononitrile, N/C-Substituted 3-hydroxyindolin-2-one, N/C-subsituted 5′-amino-2,2”-dioxodispiro[indoline-3,2′-furan-3′,3”-indoline]-4′-carbonitrile, Cinchonine BaseCyclization, Michael, Michael Addition, Spirocyclization
Amination, ethyl 2-oxocyclopentane-1-carboxylate, dibenzyl (E)-diazene-1,2-dicarboxylate, dibenzyl (R)-1-(1-(ethoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate, Cinchonine BaseAmination
Wolff rearrangement, 5-diazo-2,2-dimethylcyclopentan-1-one, quinolin-8-amine, (S)-2,2-dimethyl-N-(quinolin-8-yl)cyclobutane-1-carboxamide, Cinchonine BaseFurther reactions, Rearrangement
Oxa-Michael addition, substituted 2-vinylbenzoic acid, substituted (R)-3-methylisobenzofuran-1(3H)-one, Cinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, Lactonization, Michael Addition, Oxa-Michael Addition
Dimerization, prop-1-en-1-one, (S,Z)-4-ethylidene-3-methyloxetan-2-one, Quinine Base[2+2]-Cycloaddition, Cycloaddition, Dimerization, Further reactions, Lactonization
Spirocyclization, (E)-1-methyl-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted 2-benzylidene-1H-indene-1,3(2H)-dione, (2’R,4’S,5’S)-1”-methyl-4′-phenyl-5′-(trifluoromethyl)dispiro[indene-2,3′-pyrrolidine-2′,3”-indoline]-1,2”,3-trione, Quinine Base[3+2]-Cycloaddition, Cyclization, Spirocyclization
Cross-Coupling, tert-butyl 2-oxo-3-phenylindoline-1-carboxylate, (E)-buta-1,3-dien-1-ylbenzene, tert-butyl (R)-2-oxo-3-phenyl-3-((R,E)-4-phenylbut-3-en-2-yl)indoline-1-carboxylate, di-μ-chlorobis(η3-2-propenyl)di-palladium, 4,4′-((3,3′-bis(3,5-bis(trifluoromethyl)phenyl)-5,5′,6,6′,7,7′,8,8′-octahydro-[1,1′-binaphthalene]-2,2′-diyl)bis(oxy))didinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepine, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCross Coupling
