Aza-Michael Addition, diacrylbenzols, N‐benzylhydroxylamine, 1,2‐benzoxazines, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAza-Michael, Cascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition Phosphination, butyl 2-cyanopentanoate, chlorodiphenylphosphane, butyl (R)-2-cyano-2-(diphenylphosphaneyl)pentanoate, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeFurther reactions, Phosphination Cyclization, O‐allyl carbamates, N-bromosuccinimide, (4S,5S)-5-bromo-4-phenyl-3-tosyl-1,3-oxazinan-2-one, O-((S)-((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)(quinolin-4-yl)methyl) phenylcarbamothioate, Dihydrocinchonine DerivativeBromination, Cyclization, Cyclization, Further Cyclizations Desymmetrization, (1R,2S)-cyclohexane-1,2-diol, oxygen, (S)-2-hydroxycyclohexan-1-one, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization Epimerization, substituted (1R,2S)-cyclohexane-1,2-diol, substituted (1S,2S)-cyclohexane-1,2-diol, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization, Isomerization Epimerization, (1R,2S)-cycloheptane-1,2-diol, (1S,2S)-cycloheptane-1,2-diol, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization, Isomerization Trifluoromethylation, (E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime, (S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Isoxazoline cyclization, Trifluoromethylation Oxa-Michael Addition, methyl (E)-4-(2-hydroxyphenyl)but-2-enoate, methyl 2-(2,3-dihydrobenzofuran-2-yl)acetate, Dihydrocinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, intramolecular Oxa-Michael Addition, Michael Addition, Oxa-Michael Addition Sulfa-Michael Addition, α,β-unsaturated N-acylated oxazolidin-2-ones, alkyl thiols, γ-thio ketones, N-[(9S)-9-(9-anthracenylmethoxy)cinchonan-6′-yl]-N′-[3,5-bis(trifluoromethyl)phenyl]-thiourea, 6´-Aminocinchonine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Michael Addition, thioester malonates, (E)-1-((4-methoxybenzyl)oxy)-2-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3S)-3-(2-((4-methoxybenzyl)oxy)phenyl)-2-(((4-methoxyphenyl)thio)carbonyl)-2-methyl-4-nitrobutanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Aza-Michael Addition, diacrylbenzols, N‐benzylhydroxylamine, 1,2‐benzoxazines, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAza-Michael, Cascade reaction, Cyclization, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition
Phosphination, butyl 2-cyanopentanoate, chlorodiphenylphosphane, butyl (R)-2-cyano-2-(diphenylphosphaneyl)pentanoate, (9S,9′′S)-9,9′′-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)] bis[10,11-dihydro-6′-methoxy-cinchonan], Dihydroquinidine DerivativeFurther reactions, Phosphination
Cyclization, O‐allyl carbamates, N-bromosuccinimide, (4S,5S)-5-bromo-4-phenyl-3-tosyl-1,3-oxazinan-2-one, O-((S)-((1S,2R,4S,5R)-5-ethylquinuclidin-2-yl)(quinolin-4-yl)methyl) phenylcarbamothioate, Dihydrocinchonine DerivativeBromination, Cyclization, Cyclization, Further Cyclizations
Desymmetrization, (1R,2S)-cyclohexane-1,2-diol, oxygen, (S)-2-hydroxycyclohexan-1-one, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization
Epimerization, substituted (1R,2S)-cyclohexane-1,2-diol, substituted (1S,2S)-cyclohexane-1,2-diol, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization, Isomerization
Epimerization, (1R,2S)-cycloheptane-1,2-diol, (1S,2S)-cycloheptane-1,2-diol, 4CzIPN, N-[(9R)-10,11-dihydrocinchonan-9-yl]-O-tert-butyl carbamate, Dihydrocinchonine DerivativeDesymmetrization, Isomerization
Trifluoromethylation, (E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime, (S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Isoxazoline cyclization, Trifluoromethylation
Oxa-Michael Addition, methyl (E)-4-(2-hydroxyphenyl)but-2-enoate, methyl 2-(2,3-dihydrobenzofuran-2-yl)acetate, Dihydrocinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, intramolecular Oxa-Michael Addition, Michael Addition, Oxa-Michael Addition
Sulfa-Michael Addition, α,β-unsaturated N-acylated oxazolidin-2-ones, alkyl thiols, γ-thio ketones, N-[(9S)-9-(9-anthracenylmethoxy)cinchonan-6′-yl]-N′-[3,5-bis(trifluoromethyl)phenyl]-thiourea, 6´-Aminocinchonine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Michael Addition, thioester malonates, (E)-1-((4-methoxybenzyl)oxy)-2-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3S)-3-(2-((4-methoxybenzyl)oxy)phenyl)-2-(((4-methoxyphenyl)thio)carbonyl)-2-methyl-4-nitrobutanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
