Michael Addition, C-succinimidyl esters, nitro olefins, substituted methyl (S)-1-butyl-3-((S)-2-nitro-ethyl)-2,5-dioxopyrrolidine-3-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeMichael, Michael Addition Aza-Michael Addition, (R,E)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-en-1-yl)-N-(1-phenylethyl)benzamide, (S)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-((R)-1-phenylethyl)isoindolin-1-one, (9S)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonine DerivativeAza-Michael, Cyclization, Further Cyclizations, Intramolecular Aza-Michael, Intramolecular cyclization, Michael Addition Atropisomer Synthesis, 1-(2-(1-naphthoyl)phenyl)-3-(o-tolyl)propan-2-one, acetic anhydride, (1S,2R)-2-(o-tolyl)-[1,1′-binaphthalen]-3-yl acetate, (9S)-9-hydroxy-1-(phenylmethyl)- cinchonanium bromide, Cinchonine DerivativeAtropisomer synthesis, Cyclization, Further Cyclizations, Intramolecular cyclization Michael Addition, 4-methyloxazole-2(3H)-thione, (E)-4-phenylbut-3-en-2-one, (R)-4-(4-methyl-2-thioxo-2,3-dihydrooxazol-5-yl)-4-phenylbutan-2-one, (9R)-cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition Michael Addition, malonates, nitroolefins, substituted (R)-(1-nitropropan-2-yl)benzene, (9S)-(9′′S)-1,1′′-[[2,2-bis[[4-[[(9S)-9-hydroxycinchonanium-1-yl]methyl]phenoxy]methyl]-1,3-propanediyl]bis(methyleneoxy-4,1-phenylenemethylene)]bis[9-hydroxy-cinchonanium bromide (1:4), Cinchonine DerivativeMichael, Michael Addition Desymmetrization, alkyne‐linked cyclohexanones, 1,2-disubstituted (1R,5S)-4-methylene-2-azabicyclo[3.3.1]nonan-6-one, silver(I) acetate, (S)-2-(diarylmethyl)pyrrolidine, N-(9R)-cinchonan-9-yl-2-(diphenylphosphino)-benzamide, Cinchonine DerivativeCyclization, Desymmetrization, Further Cyclizations, Intramolecular cyclization Alkylation, N,N’-bis(4-methoxybenzyl)-[1,1′-biphenyl]-4-sulfonimidamide, benzyl bromide, (S)-N-benzyl-N,N’-bis(4-methoxybenzyl)-[1,1′-biphenyl]-4-sulfonimidamide, (9S)-1-[(4-cyanophenyl)methyl]-1′-[(2,5-difluorophenyl)methyl]-9-hydroxy-cinchonanium bromide (1:2), Cinchonine DerivativeAlkylation, Alkylation, Desymmetrization Cyclization, ketimines, alpha-isocyanoacetonitriles, 4,5,5-trisubstituted 1-(diphenylphosphoryl)-4,5-dihydro-1H-imidazole-4-carbonitrile, copper(II) triflate, N-(9R)-Cinchonan-9-yl-2-pyridinecarboxamide, Cinchonine DerivativeCyclization, Cyclization, Further Cyclizations Kinetic Resolution, 2‐sulfonylalkyl phenols, allenic esters, ethyl (S,E)-3-(2-(phenyl(tosyl)methyl)phenoxy)but-2-enoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan, Dihydrochinchonine DerivativeAlkylation, Allylation, Dynamic Kinetic Resolution, Resolution Dearomatization, substituted 1-((2-((1H-indol-3-yl)methyl)phenyl)ethynyl)naphthalen-2-ol, substituted (5aR,10aR)-10,10a-dihydro-5H-benzo[5,6]naphtho[2′,3′:3,4]chromeno[2,3-b]indole, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeCyclization, Dearomatization, Further Cyclizations, Further reactions, Intramolecular cyclization, Spirocyclization« Older EntriesNext Entries »
Michael Addition, C-succinimidyl esters, nitro olefins, substituted methyl (S)-1-butyl-3-((S)-2-nitro-ethyl)-2,5-dioxopyrrolidine-3-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeMichael, Michael Addition
Aza-Michael Addition, (R,E)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-en-1-yl)-N-(1-phenylethyl)benzamide, (S)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-((R)-1-phenylethyl)isoindolin-1-one, (9S)-1-[[4-(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonine DerivativeAza-Michael, Cyclization, Further Cyclizations, Intramolecular Aza-Michael, Intramolecular cyclization, Michael Addition
Atropisomer Synthesis, 1-(2-(1-naphthoyl)phenyl)-3-(o-tolyl)propan-2-one, acetic anhydride, (1S,2R)-2-(o-tolyl)-[1,1′-binaphthalen]-3-yl acetate, (9S)-9-hydroxy-1-(phenylmethyl)- cinchonanium bromide, Cinchonine DerivativeAtropisomer synthesis, Cyclization, Further Cyclizations, Intramolecular cyclization
Michael Addition, 4-methyloxazole-2(3H)-thione, (E)-4-phenylbut-3-en-2-one, (R)-4-(4-methyl-2-thioxo-2,3-dihydrooxazol-5-yl)-4-phenylbutan-2-one, (9R)-cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, malonates, nitroolefins, substituted (R)-(1-nitropropan-2-yl)benzene, (9S)-(9′′S)-1,1′′-[[2,2-bis[[4-[[(9S)-9-hydroxycinchonanium-1-yl]methyl]phenoxy]methyl]-1,3-propanediyl]bis(methyleneoxy-4,1-phenylenemethylene)]bis[9-hydroxy-cinchonanium bromide (1:4), Cinchonine DerivativeMichael, Michael Addition
Desymmetrization, alkyne‐linked cyclohexanones, 1,2-disubstituted (1R,5S)-4-methylene-2-azabicyclo[3.3.1]nonan-6-one, silver(I) acetate, (S)-2-(diarylmethyl)pyrrolidine, N-(9R)-cinchonan-9-yl-2-(diphenylphosphino)-benzamide, Cinchonine DerivativeCyclization, Desymmetrization, Further Cyclizations, Intramolecular cyclization
Alkylation, N,N’-bis(4-methoxybenzyl)-[1,1′-biphenyl]-4-sulfonimidamide, benzyl bromide, (S)-N-benzyl-N,N’-bis(4-methoxybenzyl)-[1,1′-biphenyl]-4-sulfonimidamide, (9S)-1-[(4-cyanophenyl)methyl]-1′-[(2,5-difluorophenyl)methyl]-9-hydroxy-cinchonanium bromide (1:2), Cinchonine DerivativeAlkylation, Alkylation, Desymmetrization
Cyclization, ketimines, alpha-isocyanoacetonitriles, 4,5,5-trisubstituted 1-(diphenylphosphoryl)-4,5-dihydro-1H-imidazole-4-carbonitrile, copper(II) triflate, N-(9R)-Cinchonan-9-yl-2-pyridinecarboxamide, Cinchonine DerivativeCyclization, Cyclization, Further Cyclizations
Kinetic Resolution, 2‐sulfonylalkyl phenols, allenic esters, ethyl (S,E)-3-(2-(phenyl(tosyl)methyl)phenoxy)but-2-enoate, (3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan, Dihydrochinchonine DerivativeAlkylation, Allylation, Dynamic Kinetic Resolution, Resolution
Dearomatization, substituted 1-((2-((1H-indol-3-yl)methyl)phenyl)ethynyl)naphthalen-2-ol, substituted (5aR,10aR)-10,10a-dihydro-5H-benzo[5,6]naphtho[2′,3′:3,4]chromeno[2,3-b]indole, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeCyclization, Dearomatization, Further Cyclizations, Further reactions, Intramolecular cyclization, Spirocyclization
