Spirocyclization, alkenyloxindoles, alkene‐substituted 1,3‐diketones, polycyclic tetrahydroxanthone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Amination, 2-bromo-N-phenylpropanamide, N-methylaniline, (S)-2-(methyl(phenyl)amino)-N-phenylpropanamide, copper iodide, N-[(S)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxy-4-quinolinyl)methyl]-8-quinolinesulfonamide, Quinine Derivativealpha-Amination, Amination Allylation, substituted N-(prop-2-yn-1-yl)formamide, substituted indoline-2,3-dione, substituted (R)-3-hydroxy-3-((S)-5-methylene-4,5-dihydrooxazol-4-yl)indolin-2-one, 3-[(3,5-dimethoxyphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAlkylation, Allylation, Cyclization, Cyclization, Further Cyclizations Cyclization, (E)-4-(2-ethynylphenyl)but-3-en-2-one, 1-benzyl-1H-pyrrole-2,5-dione, (3aR,7S,7aS)-2-benzyl-7-(2-ethynylphenyl)tetrahydro-1H-isoindole-1,3,5(2H,4H)-trione, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeCyclization, Cyclization, Further Cyclizations Spirocyclization, substituted 3-iminoindolin-2-one, substituted 4-(prop-2-yn-1-yl)-2,4-dihydro-3H-pyrazol-3-one, bispiro[oxindole-pyrrolidine-pyrazolone] derivatives, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich, Spirocyclization Atropisomer Synthesis, 1-((2-(9H-carbazol-9-yl)phenyl)ethynyl)naphthalen-2-ol, N-bromosuccinimide, azepine skeletons, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAtropisomer synthesis, Bromination, Cyclization, Cyclization, Further Cyclizations Atropisomer Synthesis, tert-butyl 7-bromo-1-methyl-6-oxoindolo[1,2-a]quinoxaline-5(6H)-carboxylate, ethyl 2-isocyanoacetate, lactam-bridged N-arylindoles, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis Cross-Coupling, alkyl bromides, 2-(4-methoxyphenyl)-1,3,4-oxadiazole, (R)-2-(4-methoxyphenyl)-5-(1-phenylpropyl)-1,3,4-oxadiazole, copper catalyst, 2-(di-9-phenanthrenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeCross Coupling Mannich reaction, β,γ-Alkynyl-α-imino esters, 1,3-diones, substituted ethyl (R)-4-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-4-carboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative[3+3]-Annulation, Cyclization, Further Cyclizations, Mannich, Mannich Atropisomer Synthesis, 1,2-diarylethynes, N-iodosuccinimide, atropisomeric heterobiaryls, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAtropisomer synthesis« Older EntriesNext Entries »
Spirocyclization, alkenyloxindoles, alkene‐substituted 1,3‐diketones, polycyclic tetrahydroxanthone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Amination, 2-bromo-N-phenylpropanamide, N-methylaniline, (S)-2-(methyl(phenyl)amino)-N-phenylpropanamide, copper iodide, N-[(S)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxy-4-quinolinyl)methyl]-8-quinolinesulfonamide, Quinine Derivativealpha-Amination, Amination
Allylation, substituted N-(prop-2-yn-1-yl)formamide, substituted indoline-2,3-dione, substituted (R)-3-hydroxy-3-((S)-5-methylene-4,5-dihydrooxazol-4-yl)indolin-2-one, 3-[(3,5-dimethoxyphenyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAlkylation, Allylation, Cyclization, Cyclization, Further Cyclizations
Cyclization, (E)-4-(2-ethynylphenyl)but-3-en-2-one, 1-benzyl-1H-pyrrole-2,5-dione, (3aR,7S,7aS)-2-benzyl-7-(2-ethynylphenyl)tetrahydro-1H-isoindole-1,3,5(2H,4H)-trione, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeCyclization, Cyclization, Further Cyclizations
Spirocyclization, substituted 3-iminoindolin-2-one, substituted 4-(prop-2-yn-1-yl)-2,4-dihydro-3H-pyrazol-3-one, bispiro[oxindole-pyrrolidine-pyrazolone] derivatives, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich, Spirocyclization
Atropisomer Synthesis, 1-((2-(9H-carbazol-9-yl)phenyl)ethynyl)naphthalen-2-ol, N-bromosuccinimide, azepine skeletons, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAtropisomer synthesis, Bromination, Cyclization, Cyclization, Further Cyclizations
Atropisomer Synthesis, tert-butyl 7-bromo-1-methyl-6-oxoindolo[1,2-a]quinoxaline-5(6H)-carboxylate, ethyl 2-isocyanoacetate, lactam-bridged N-arylindoles, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis
Cross-Coupling, alkyl bromides, 2-(4-methoxyphenyl)-1,3,4-oxadiazole, (R)-2-(4-methoxyphenyl)-5-(1-phenylpropyl)-1,3,4-oxadiazole, copper catalyst, 2-(di-9-phenanthrenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeCross Coupling
Mannich reaction, β,γ-Alkynyl-α-imino esters, 1,3-diones, substituted ethyl (R)-4-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-4-carboxylate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative[3+3]-Annulation, Cyclization, Further Cyclizations, Mannich, Mannich
Atropisomer Synthesis, 1,2-diarylethynes, N-iodosuccinimide, atropisomeric heterobiaryls, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeAtropisomer synthesis
