Organocatalytic Asymmetric Direct Vinylogous Michael Initiated Ring Closure Reaction of 4-Nitroisoxazole Derivatives to 3-Isopropylidene Oxindoles.

DOI Number:

10.1021/acs.joc.3c02125

Reaction Category:

Educt:

tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, 5-(chloromethyl)-3-methyl-4-nitroisoxazole

Product:

tert-butyl (1R,3S)-2,2-dimethyl-3-(3-methyl-4-nitroisoxazol-5-yl)-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-carboxylate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylurea

Cas No:

957770-67-1

Cas No:

485-71-2