Direct catalytic enantioselective vinylogous aldol reaction of allyl ketones to pyrazole-4,5-diones.

DOI Number:

10.1021/acs.joc.8b01566
Link to literature

Reaction Category:

Aldol | Vinylogous Aldol

RXNO ID:

RXNO_0000016

Educt:

pyrazole-4,5-diones, allyl ketones

Product:

substituted (R,E)-4-hydroxy-4-(4-oxopent-2-en-1-yl)-2,4-dihydro-3H-pyrazol-3-one

Catalyst:

N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,5-bis(trifluoromethyl)-benzamide

Cas No:

1799320-84-5

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0