Alkynyl Cinchona Catalysts affect Enantioselective Trifluoromethylation for Efavirenz under Metal-Free Conditions.

DOI Number:

10.1021/acs.orglett.6b02807

Reaction Category:

MOP ID:

MOP_0000368

Educt:

1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one, trimethyl(trifluoromethyl)silane

Product:

(S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol

Catalyst:

(8α,9R)-9-butoxy-10,11-didehydro-6′-methoxy- 1-[[3,3′′,5,5′′-tetrakis(trifluoromethyl) [1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-Cinchonanium bromide

Cas No:

2021241-34-7

Cas No:

130-95-0