Enantioselective sulfa-Michael addition reaction of methyl thioglycolate to chalcones derivatives with sterically encumbered quinine squaramide organocatalyst.
DOI Number:
10.1016/j.tetlet.2018.02.068
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
methyl 2-mercaptoacetate, (E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
Product:
methyl (R)-2-((1-(4-methoxyphenyl)-3-oxo-3-phenylpropyl)thio)acetate
Catalyst:
3-[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]-4- (tricyclo[3.3.1.13,7]dec-2-ylamino)-3- cyclobutene-1,2-dione
Cas No:
1877237-86-9
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0