Organocatalytic enantioselective sulfa-Michael addition of thiocarboxylic acids to β-trifluoromethyl-α, β-unsaturated ketones for the construction of stereogenic carbon center bearing a sulfur atom and a trifluoromethyl group.
DOI Number:
10.1016/j.tet.2019.02.040
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
β-trifluoromethyl-α,β-unsaturated ketones, thiocarboxylic acids
Product:
substituted S-(1,1,1-trifluoro-4-oxobutan-2-yl) methanethioate
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0