Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect.

DOI Number:

10.1021/ol201316z

Reaction Category:

RXNO ID:

RXNO_0000207

Educt:

trifluoromethyl ketoimines, trimethylsilanecarbonitrile

Product:

(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-phenylpropanenitrile

Catalyst:

N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]- Thiourea

Cas No:

1229440-70-3

Cas No:

1435-55-8