Asymmetric synthesis of trifluoromethyl-substituted 3, 3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1, 3-dipolar cycloaddition reactions.
DOI Number:
10.1039/C6QO00723F
Reaction Category:
Educt:
substituted (Z)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted 1-methyl-3-methyleneindolin-2-one
Product:
substituted (3R,3'R,5'S)-1''-methyl-5'-(trifluoromethyl)dispiro[indoline-3,2'-pyrrolidine-3',3''-indoline]-2,2''-dione
Catalyst:
3-[(8α,9S)-cinchonan-9-ylamino]-4-[[(1R)-1-phenylethyl]amino]-3-Cyclobutene-1,2-dione
Cas No:
2089422-79-5
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2