Enantioselective Synthesis of Functionalized Diazaspirocycles from 4‐Benzylideneisoxazol‐5 (4H)‐one Derivatives and Isocyanoacetate Esters.

DOI Number:

10.1002/adsc.202000611
Link to literature

Reaction Category:

Cyclization | Spirocyclization

MOP ID:

MOP_0000561

Educt:

substituted (E)-4-ethylideneisoxazol-5(4H)-one, substituted 2-cyanoacetate

Product:

substituted (3S,4S,5S)-6-oxo-7-oxa-1,8-diazaspiro[4.4]non-8-ene-3-carboxylate

Catalyst:

3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1610724-48-5

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0