Enantioselective construction of chiral bispiro [oxindole-pyrrolidine-pyrazolone] derivatives via sequential and one-pot mannich/hydroamination reaction.

DOI Number:

10.1021/acs.joc.1c02428

Reaction Category:

RXNO ID:

RXNO_0000032

Educt:

substituted 3-iminoindolin-2-one, substituted 4-(prop-2-yn-1-yl)-2,4-dihydro-3H-pyrazol-3-one

Product:

bispiro[oxindole-pyrrolidine-pyrazolone] derivatives

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1210360-60-3

Associated Product from Buchler GmbH:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1210360-60-3