Asymmetric Synthesis of 2′‐Trifluoromethylated Spiro‐pyrrolidine‐3, 3′‐oxindoles via Squaramide‐Catalyzed Umpolung and 1, 3‐Dipolar Cycloaddition.

DOI Number:

10.1002/adsc.201600688
Link to literature

Reaction Category:

[3+2]-Cycloaddition | Cycloaddition | Spirocyclization

MOP ID:

MOP_0000715

Educt:

(E)-7-chloro-3-ethylidene-1-methylindolin-2-one, diethyl 2-((2,2,2-trifluoroethyl)imino)malonate

Product:

diethyl (2'R,3R,4'S)-7-chloro-1,4'-dimethyl-2-oxo-2'-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-5',5'-dicarboxylate

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [(8α,9S)-cinchonan-9-ylamino]- 3-Cyclobutene-1,2-dione

Cas No:

1256245-86-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2