Chiral Squaramide-Catalyzed Michael/­Alkylation Cascade Reaction for the Asymmetric Synthesis of Nitro-Spirocyclopropanes.

DOI Number:

10.1002/ejoc.201500533
Link to literature

Reaction Category:

Cascade reaction | Spirocyclization

Educt:

(E)-3-arylenechroman-4-one or (E)-2-arylideneindan-1-one derivatives, bromo(nitro)methane

Product:

nitro-spirocyclopropanes

Catalyst:

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1352957-59-5

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7