Quaternary carbon center forming [3+2] cyclization reaction by adjusting the substituents of substrates.
DOI Number:
10.1021/acs.joc.9b02041
Reaction Category:
Educt:
diethyl (E)-2-((2-hydroxybenzylidene)amino)malonate, tert-butyl (E)-2-oxo-3-(2,2,2-trifluoroethylidene)indoline-1-carboxylate
Product:
1-(tert-butyl) 5',5'-diethyl (2'S,3S,4'R)-2'-(2-hydroxyphenyl)-2-oxo-4'-(trifluoromethyl)spiro[indoline-3,3'-pyrrolidine]-1,5',5'-tricarboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7