Diastereodivergent aminocatalyzed spirocyclization strategies using 4-alkylideneisoxazol-5-ones and methyl vinyl ketones.

DOI Number:

10.1039/D0QO00779J
Link to literature

Reaction Category:

Spirocyclization

Educt:

4-alkylideneisoxazol-5-ones, methyl vinyl ketones

Product:

6,10-disubstituted (6S,10S)-4-methyl-2-oxa-3-azaspiro[4.5]dec-3-ene-1,8-dione

Catalyst:

(9R)-6′-methoxy-cinchonan-9-amine

Cas No:

287979-82-2

Associated Product from Buchler GmbH:

Quinidine Base

Cas No:

56-54-2