Stereodivergent synthesis of enantioenriched 2,3-disubstituted dihydrobenzofurans via a one-pot C–H functionalization/oxa-michael addition cascade.

DOI Number:

10.1021/jacs.1c03498

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

3-(pyrrolidin-1-yl)phenol, 2,6-dichlorophenyl (E)-2-diazo-4-phenylbut-3-enoate

Product:

2,3-disubstituted dihydrobenzofurans

Catalyst:

rhodium catalyst, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7