One-pot enantioselective synthesis of 2-pyrrolidinone derivatives bearing a trifluoromethylated all-carbon quaternary stereocenter.
DOI Number:
10.1021/acs.orglett.9b03758
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
tert-butyl (Z)-3-(3-ethoxy-1,1,1-trifluoro-3-oxopropan-2-ylidene)-2-oxoindoline-1-carboxylate, nitromethane
Product:
tert-butyl (S)-3-((S)-3-ethoxy-1,1,1-trifluoro-2-(nitromethyl)-3-oxopropan-2-yl)-2-oxoindoline-1-carboxylate
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-86-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2