Subtle Structural Tuning Enables Bifunctional Cinchona Alkaloid Thiourea and Chiral Pyridine-Oxazoline Ligands To Work Synergistically with Copper To Catalyze an Enantioselective Micheal Addition.
DOI Number:
10.1021/acs.joc.5c02125
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
substituted 3-amino-1H-pyrrole-2,5-dione, 2,6-di-tert-butyl-4-(2-hydroxybenzylidene)cyclohexa-2,5-dien-1-one
Product:
substituted (S)-3-amino-4-((3,5-di-tert-butyl-4-hydroxyphenyl)(2-hydroxyphenyl)methyl)-1H-pyrrole-2,5-dione
Catalyst:
copper catalyst, 1-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3-(6-((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridin-2-yl)thiourea
Cas No:
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0