Control of diastereoselectivity in tandem asymmetric reactions generating nonadjacent stereocenters with bifunctional catalysis by cinchona alkaloids.

DOI Number:

10.1021/ja0670409

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

S-methyl 2-cyanopropanethioate, 2-chloroacrylonitrile

Product:

S-methyl (2R,4R)-4-chloro-2,4-dicyano-2-methylbutanethioate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-25-8

Cas No:

56-54-2