Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin.

DOI Number:

10.1021/acs.oprd.1c00394

Reaction Category:

Educt:

nitroalkene, dimethyl malonate

Product:

dimethyl (S)-2-(4-methyl-1-nitropentan-2-yl)malonate

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1363811-07-7

Cas No:

1435-55-8