Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin.
DOI Number:
10.1021/acs.oprd.1c00394
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
nitroalkene, dimethyl malonate
Product:
dimethyl (S)-2-(4-methyl-1-nitropentan-2-yl)malonate
Catalyst:
3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1363811-07-7
Associated Product from Buchler GmbH:
Dihydroquinidine Base
Cas No:
1435-55-8