Michael addition–lactonization of arylacetyl phosphonate to β,γ-unsaturated α-keto esters for the synthesis of chiral syn-3,4-dihydropyranones and 5, 6-dihydropyranones.
DOI Number:
10.1021/acs.orglett.6b02558
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
diethyl (2-phenylacetyl)phosphonate, methyl (E)-2-oxo-4-phenylbut-3-enoate
Product:
methyl (3R,4S)-2-oxo-3,4-diphenyl-3,4-dihydro-2H-pyran-6-carboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7