Squaramide-catalyzed domino Michael/aza-Henry [3+2] cycloaddition: asymmetric synthesis of functionalized 5-trifluoromethyl and 3-nitro substituted pyrrolidines.
DOI Number:
10.1039/C7QO00161D
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
diethyl 2-((2,2,2-trifluoroethyl)imino)malonate, nitroalkenes
Product:
4-substituted diethyl (3R,5R)-3-nitro-5-(trifluoromethyl)pyrrolidine-2,2-dicarboxylate
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7