Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides.
DOI Number:
10.1039/C8OB01588K
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
2-enoylpyridines, pyrazolin-5-ones, acetic anhydride
Product:
(R)-4-(1-aryl-3-oxo-3-(pyridin-2-yl)propyl)-3-methyl-1-phenyl-1H-pyrazol-5-yl acetate
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-86-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2