Enantioselective synthesis of cyclic thioureas via mannich reaction and concise synthesis of highly optically active methylthioimidazolines: discovery of a more potent antipyretic agent.
DOI Number:
10.1002/adsc.201100288
Reaction Category:
MOP ID:
MOP_0000561
Educt:
substituted 4-methyl-N-methylenebenzenesulfonamide, 3-(2-isothiocyanatoacetyl)-4,4-dimethyloxazolidin-2-one
Product:
cyclic thioureas
Catalyst:
N-[(8α,9S)-6′-methoxycinchonan-9-yl]-N′-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenyl]methyl]-thiourea
Cas No:
1311961-50-8
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0