Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines.

DOI Number:

10.1039/C5RA17075C

Reaction Category:

RXNO ID:

RXNO_0000032

Educt:

isatin-derived ketimines, isocyanoacetates

Product:

substituted 2-((R)-3-((tert-butoxycarbonyl)amino)-2-oxoindolin-3-yl)-2-isocyanoacetate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-25-8

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-25-8