Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R)‐Sitagliptin.

DOI Number:

10.1002/anie.201605167

Reaction Category:

Educt:

imines, dithiomalonates

Product:

S,S-dibenzyl (S)-2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)propanebis(thioate)

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione

Cas No:

1210360-60-3

Cas No:

130-95-0