Organocatalytic asymmetric construction of tetrasubstituted carbon stereocenters bearing three heteroatoms via intramolecular cyclization of vinylidene ortho-quinone methide with imidates.

DOI Number:

10.1021/acs.orglett.2c01842

Reaction Category:

Educt:

methyl (E)-N-(2-((2-hydroxynaphthalen-1-yl)ethynyl)phenyl)isobutyrimidate, N-Bromsuccinimid

Product:

1-bromopyrrolidine-2,5-dione--(8S)-14-bromo-8-isopropyl-8-methoxy-14,14a-dihydro-8H-naphtho[1',2':5,6][1,3]oxazino[3,4-a]indole

Catalyst:

N-[(8α,9S)-6′-Methoxycinchonan-9-yl]- 4-(trifluoromethyl)benzamide

Cas No:

2768033-07-2

Cas No:

130-95-0