Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF3 Group from 2,2,2-Trifluoroacetophenone Substrates.

DOI Number:

10.6023/cjoc201612006
Link to literature

Reaction Category:

Henry | Henry

RXNO ID:

RXNO_0000086

Educt:

trifluoro-1-phenylethan-1-one, nitromethane

Product:

1,1,1-trifluoro-3-nitro-2-phenylpropan-2-ol

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7