A highly enantioselective Friedel–Crafts reaction of 3,5-dimethoxylphenol with nitroolefins mediated by a bifunctional quinine derived thiourea catalyst.
DOI Number:
10.1039/C7OB00372B
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
3,5-dimethoxylphenol, nitroolefins
Product:
substituted (R)-3,5-dimethoxy-2-(2-nitro-1-phenylethyl)phenol
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7