Enantioselective synthesis of (−)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction.
DOI Number:
10.1039/C5OB02141C
Reaction Category:
MOP ID:
MOP_0000561
Educt:
4-nitrobenzaldehyde, benzhydryl 2-cyanoacetate
Product:
benzhydryl (4R,5S)-5-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxylate
Catalyst:
silver oxide, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide
Cas No:
1630973-06-6
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7