Enantioselective Silver and Amine Co‐catalyzed Desymmetrizing Cycloisomerization of Alkyne‐Linked Cyclohexanones.

DOI Number:

10.1002/anie.201612048
Link to literature

Reaction Category:

Cyclization | Desymmetrization | Further Cyclizations | Intramolecular cyclization

MOP ID:

MOP_0000561

Educt:

alkyne‐linked cyclohexanones

Product:

1,2-disubstituted (1R,5S)-4-methylene-2-azabicyclo[3.3.1]nonan-6-one

Catalyst:

silver(I) acetate, (S)-2-(diarylmethyl)pyrrolidine, N-(9R)-cinchonan-9-yl-2-(diphenylphosphino)-benzamide

Cas No:

1263322-11-7

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5