Cinchona Alkaloid/TiIV‐Catalyzed Enantioselective Enamine–Trifluoropyruvate Condensation–Cyclization Reaction and Its Application to Drug‐like Heterocycles.
DOI Number:
10.1002/chem.201000911
Reaction Category:
MOP ID:
MOP_0000561
Educt:
3-(benzhydrylamino)cyclohex-2-en-1-one, ethyl 3,3,3-trifluoro-2-oxopropanoate
Product:
(S)-1-benzhydryl-3-hydroxy-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
Catalyst:
1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]oxy]-9,10-Anthracenedione
Cas No:
176097-24-8
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7