Enantioselective syntheses of 4 H-3, 1-benzoxazines via catalytic asymmetric chlorocyclization of o-vinylanilides.

DOI Number:

10.1021/acs.joc.9b02395
Link to literature

Reaction Category:

Chlorination | Cyclization

MOP ID:

MOP_0000551

Educt:

substituted N-(2-vinylphenyl)amide, 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione

Product:

substituted (S)-4-(chloromethyl)-4H-benzo[d][1,3]oxazine

Catalyst:

9-[2-[bis(2-methylphenyl)amino]benzoate]-(8α,9R)-Cinchonan-9-ol

Cas No:

2084883-75-8

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2