Synthesis of six-membered spirocyclic oxindoles with five consecutive stereocenters in an asymmetric organocatalytic one-pot Michael/Michael/aldol addition sequence.

DOI Number:

10.1021/jo302655u

Reaction Category:

Educt:

substituted indolin-2-one, nitroalkenes, α,β-unsaturated aldehydes

Product:

spirocyclic oxindoles

Catalyst:

(S)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7