Highly enantioselective cascade reaction catalyzed by squaramides: the synthesis of CF3-containing chromanes.

DOI Number:

10.1021/acs.orglett.5b01799
Link to literature

Reaction Category:

Cascade reaction

Educt:

substituted (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one, substituted (E)-3,3,3-trifluoro-1-nitroprop-1-ene

Product:

CF3-containing chromanes

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-86-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2