Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines.

DOI Number:

10.1039/C2CC18049A
Link to literature

Reaction Category:

Cascade reaction

Educt:

(E)-4,4,4-trifluoro-1-(4-methoxyphenyl)but-2-en-1-one, nitromethane

Product:

(S)-5-(4-methoxyphenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrole

Catalyst:

iron, acetic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea

Cas No:

890044-38-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2