Asymmetric Catalytic Access to Piperazin-2-ones and Morpholin-2-ones in a One-Pot Approach: Rapid Synthesis of an Intermediate to Aprepitant.
DOI Number:
10.1021/acs.joc.2c02491
Reaction Category:
Educt:
4-cyanobenzaldehyde, 2-(phenylsulfonyl)acetonitrile, benzathine
Product:
(R)-4-(1,4-dibenzyl-3-oxopiperazin-2-yl)benzonitrile
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]urea
Cas No:
957770-66-0
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0