Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process.

DOI Number:

10.1039/C2CC36578B
Link to literature

Reaction Category:

Bromination | Cyclization | Further Cyclizations | Intramolecular cyclization

MOP ID:

MOP_0000551

Educt:

(E)-N-(5-substituted-pent-4-en-1-yl)-4-nitrobenzenesulfonamide, 1,3-Dibromo-5,5-Dimethylhydantoin

Product:

2-substituted (2R,3S)-3-bromo-1-((4-nitrophenyl)sulfonyl)piperidine

Catalyst:

(8α,9R)-9-[N-(2,4-dimethoxyphenyl)carbamothioate]-6′-(2,2-dimethylpropoxy)-cinchonan-9-ol

Cas No:

1431969-18-4

Associated Product from Buchler GmbH:

Cupreine Base

Cas No:

524-63-0