An enantio-and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis–Hillman reaction.
DOI Number:
10.1016/S0040-4039(01)01676-8
Reaction Category:
Educt:
(9H-fluoren-9-yl)methyl (S)-(4-methyl-1-oxopentan-2-yl)carbamate, 1,1,1,3,3,3-hexafluoropropan-2-yl acrylate, sodium methanolate
Product:
methyl (3S,4S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-6-methyl-2-methyleneheptanoate
Catalyst:
(3α,9S)-3,9-epoxy-10,11-dihydro-cinchonan-6′-ol
Cas No:
253430-48-7
Associated Product from Buchler GmbH:
Dihydrocupreidine Base
Cas No:
73522-75-5